One of the most widely used additives currently in medicine and supplements is Magnesium stearate. Such supplements are present in supplements sold on the market. But it is often called another name, such as "vegetable stearate" or "stereo acid", which is almost everywhere.
Although this additive is ubiquitous, magnesium stearate is also one of the most controversial ingredients in the supplement world. In some respects, it is similar to the controversy over vitamin B17, and there is controversy as to whether this additive is a poison or a cure for cancer. Most importantly: Like most fillers and bulk additives, magnesium stearate is not good for the human body at high doses, but it is definitely not as badly harmful as some products, because it can usually only be used in very small doses.
What is magnesium stearate?
Magnesium stearate is a magnesium salt of stearic acid. Basically, magnesium stearate contains two compounds of stearic acid and magnesium. Stearic acid is a saturated fatty acid in many foods, including animal and vegetable fats and oils. Cocoa and flaxseed are examples of foods that contain large amounts of stearic acid.
After magnesium stearate is broken down into components in the body, its fat is essentially the same as stearic acid. Some sources even claim that its magnesium portion can be used to provide essential minerals to the body. Given the widespread prevalence of magnesium deficiency, this suggests that magnesium stearate is actually good for the body.
Uses of magnesium stearate
Magnesium stearate is the most common ingredient used to form tablets because it is a magical lubricant. It's called a "flowing agent" and it helps speed up the manufacturing process because it prevents ingredients from sticking to mechanical equipment. A negligible amount is required to apply a powder mixture to almost any drug or supplement mixture.
Not only can magnesium stearate be transported smoothly on the machine that produces the pill, it also makes it easier to swallow the pill and move it down the gastrointestinal tract. Magnesium stearate is also a common excipient, which means that it helps to enhance the therapeutic effect of the active ingredients of various drugs to promote drug absorption and solubility. It is known as a safe carrier for drugs, and excipients also help To give the pills a uniform consistency.
Some people claim that drugs or supplements can be produced without excipients such as magnesium stearate, which is why they are used with more natural alternatives. This may not be the case. In very popular terms: some magnesium stearate alternatives are now being reformulated, using natural excipients such as ascorbyl palmitate, and it makes sense not to misunderstand science. However, these alternatives are not always effective and they also have different physical properties. It is unclear whether magnesium stearate alternatives are possible or needed.
Potential side effects of magnesium stearate
Like other chelated minerals, this mineral has no fixed negative effects because it contains stable neutral compounds composed of minerals and edible acids. On the other hand, overdose of magnesium can impair neuromuscular conduction and, although very rare, can also lead to weakness and diminished reflexes.
Rare things can sometimes happen, and severe toxicities are most common after intravenous infusion over several hours, and can occur after chronic overdose, especially in cases of renal insufficiency. Serious toxicity is reported after acute ingestion, but it is very rare. Still, this report has not reassured everyone.
Suppress T cells
As a key component of the human immune system's attack on pathogens, T cells are not directly affected by magnesium stearate, but are affected by steric acid (the main component of ordinary fillers).
In a study evaluating common excipients in Japan, plant magnesium stearate was actually found to be a formaldehyde initiator! However, this may not be as scary as it sounds, as many fresh fruits, vegetables and animal products contain formaldehyde. Magnesium stearate produces the smallest amount of formaldehyde per gram of excipient. For example, eating dried mushrooms can produce 406 milligrams of formaldehyde per kilogram!
The World Health Organization released a report outlining how several batches of magnesium stearate were contaminated with potentially harmful chemicals. Because this is an isolated incident, we cannot conclude prematurely that those taking supplements and prescription drugs containing magnesium stearate should be concerned about toxic contamination.
Before resisting all supplements and natural health foods, it's important to consider "dose dependence." In other words, with the exception of intravenous overdose under severe medical conditions, magnesium stearate has only been shown to be harmful in laboratory studies in which rats were forced to feed too high amounts on Earth No one can consume that much.
The study used 40 rats and fed 0%, 5%, 10%, or 20% magnesium stearate on a semi-synthetic diet for 3 months. The 20% group was found to have reduced weight gain, decreased liver weight, and increased iron, kidney stones, and renal calcium deposits. 10% group: liver weight was reduced. 0%-5% group: no side effects were observed, equivalent to less than 2500 mg per kilogram of body weight per day.
This indicates that the amounts of stearic acid and magnesium stearate commonly used in tablets are relatively small. Stearic acid is usually between 0.5% and 10% of the tablet weight, while magnesium stearate is usually between 0.25% and 1.5% of the tablet weight. Therefore, in a 500 mg tablet, the amount of stearic acid may be about 25 mg and the amount of magnesium stearate is about 5 mg.
In fact, magnesium stearate and all its derivatives are cost-effective additives for pharmaceutical and supplement manufacturers. At the same time, however, they pose little or no threat to those who consume it as part of a natural health supplement. All reports claiming that fillers can cause harm are not based on science at all.
I have sorted out the effects and side effects of magnesium stearate in supplements on the human body, and hope to bring a little reference value to everyone. In fact, the author believes that taking too much of anything is always harmful to the body and not beneficial. So it's important to keep this in mind, because if someone is hurt by magnesium stearate, that person needs to consume thousands of capsules or tablets in a day!